Table of Contents

Contributors vii

Preface ix

1 General Principles of Toxicology 1
Robert C. James, Stephen M. Roberts, and Phillip L. Williams

2 Xenobiotic Absorption, Distribution, Metabolism, and Excretion 29
Michael R. Franklin

3 Toxicokinetics 59
Rebecca A. Clewell and Harvey J. Clewell III

4 Omics Technologies in Toxicology 89
Mary Jane Cunningham

5 Toxicity of the Hematopoietic System 103
Sherilyn A. Gross

6 Hepatotoxicity: Toxic Effects on the Liver 125
Robert C. James and Stephen M. Roberts

7 Nephrotoxicity: Toxic Responses of the Kidney 139
Lawrence H. Lash

8 Neurotoxicity: Toxic Effects on the Nervous System 157
William M. Caudle and Gary W. Miller

9 Dermatotoxicity: Toxic Effects on the Skin 169
Sailesh Konda and Howard I. Maibach

10 Pulmonotoxicity: Toxic Effects in the Lung 179
Cuiqing Liu and Qinghua Sun

11 Immunotoxicity: Toxic Effects on the Immune System 197
Eric S. Sobel and Stephen M. Roberts

12 Toxic Effects on Reproduction 211
Mary L. Hixon

13 Developmental Toxicology 223
Vincent F. Garry and Peter L. Truran

14 Mutagenesis and Genetic Toxicology 235
Martha M. Moore, Meagan B. Myers, and Robert H. Heflich

15 Chemical Carcinogenesis 259
James E. Klaunig

16 Properties and Effects of Metals 283
David B. Mayfield, Ari S. Lewis, Lisa A. Bailey, and Barbara D. Beck

17 Properties and Effects of Pesticides 309
Janice Britt

18 Properties and Effects of Solvents and Solvent-Like Chemicals 325
Christopher M. Teaf, Michele M. Garber, and J. Michael Kuperberg

19 Nanotoxicology 359
Hongbo Ma, Steve Diamond, Georgia Hinkley, and Stephen M. Roberts

20 Computational Toxicology 373
Richard S. Judson, David M. Reif, and Keith A. Houck

21 E pidemiological Issues in Occupational and Environmental Health 391
Michael S. Bloom and John E. Vena

22 Occupational and Environmental Health 411
Brenda S. Buikema, T. Renée Anthony, and Fredric Gerr

23 Human Health Risk Assessment 425
Leah D. Stuchal, Robert C. James, and Stephen M. Roberts

Glossary 457

Index 471

About the Author

Stephen M. Roberts, PhD, is Professor and Program Director of the Center for Environmental and Human Toxicology at the University of Florida, Gainesville Robert C. James, PhD, is Senior Principal Scientisst, ToxStrategies, Inc., Tallahassee, Florida, and Associate Scientist at the Center for Environmental and Human Toxicology at the University of Florida, Gainesville Phillip L. Williams, PhD, is Dean & Georgia Power Professor at the University of Georgia, Athens