Part I: Aetiology of Insulin Resistance and Type 2 Diabetes: Prevalence and Consequences of the “Diabesity” Epidemic
Chapter 1: The Increasing Burden of Type 2 Diabetes:
Magnitude, Causes, and Implications of the Epidemic
Edward W. Gregg, PhD, and Andrea K. Kriska, PhD
Trends in Prevalence and Incidence
Risk Factors for Diabetes and Causes of the Epidemic
Determinants of Recent Trends in the Epidemic
Anticipated Consequences of Diabetes and the Outlook for
Prevention
Concluding Remarks
Chapter 2: Waging War on Type 2 Diabetes: Primary
Prevention Through Exercise Biology
Frank W. Booth, Manu V. Chakravarthy, and Matthew J. Laye
Scope of the Problem
Rationale for action
Physical Inactivity's Contributing Role in the Pathogenesis of
Diabetes
New Ammunitions
Future Battle Plans
Concluding Remarks
Part II: Defects in Metabolism and Insulin Resistance
Chapter 3: Fatty Acid Uptake and Insulin Resistance
Arend Bonen, Adrian Chabowski, Jan F.C. Glatz, and Joost J.F.P.
Luiken
LCFAS and Their Uptake Across the Sarcolemma
Fatty Acid Transporters
Fatty Acid Transport and Transporters in Human Obesity and Type 2
Diabetes
Concluding Remarks
Chapter 4: Lipid Metabolism and Insulin Signaling
Jason R. Berggren, Leslie A. Consitt, and Joseph A. Houmard
Lipid Metabolism in Skeletal Muscle
The Insulin-Signaling Pathway
Does Lipid Exposure Impair Insulin Action?
Perturbations in Lipid Metabolism, Insulin Signal Transduction, and
Insulin Action With Type 2 Diabetes and Obesity
The Exercise Paradox
Effect of Weight Loss on Muscle Lipid Accumulation and Insulin
Signaling
Concluding Remarks
Chapter 5: Metabolic Inflexibility and Insulin
Resistance
Bret Goodpaster, PhD, and David E. Kelley, MD
Substrate Utilization During Resting Conditions in Lean, Healthy
Individuals
Substrate Utilization in Insulin-Resistant Individuals
Potential Cellular Mechanisms for Metabolic Flexibility in Fat
Oxidation
Effects of Weight Loss on Metabolic Flexibility in Obesity and
T2DM
Effects of Exercise Training on Metabolic Flexibility in Obesity
and T2DM
Concluding Remarks
Chapter 6: Nutrient Sensor Links Obesity With Diabetes
Risk
Sarah Crunkhorn and Mary Elizabeth Patti
Nutrient Sensing and Control of Food Intake
Overnutrition, Disruption of Homeostatic Control, and Insulin
Resistance
Cellular Nutrient Sensing
Concluding Remarks
Chapter 7: Inflammation-Induced Insulin Resistance in
Obesity: When Immunity Affects Metabolic Control
Phillip James White and Andrᅵ Marette
Obesity Is a Chronic Low-Grade Inflammatory State
Evolution of Inflammation in Obesity
Lipid Mediators
Protein Kinase Mediators
Transcriptional Mediators
Concluding Remarks
Part III: Prevention of Type 2 Diabetes Through Exercise Training
Chapter 8: Transcription Factors Regulating Exercise
Adaptation
David Kitz Krï¿œmer and Anna Krook
Activation of MAP Kinase Signaling
Factor of Activated T Cells (NFAT)
Regulation of GLUT4 Expression
Mitochondria Biogenesis and Increased Lipid Oxidation
Exercise-Mediated Regulation of PPARs
Peroxisome Proliferators Activated Receptor Gamma Coactivator
(PGC)-1
Concluding Remarks
Chapter 9: Exercise and Calorie Restriction Use Different
Mechanisms to Improve Insulin Sensitivity
Gregory D. Cartee, PhD
Exercise and Calorie Restriction Effects on Skeletal Muscle Energy
Status
Exercise/Contraction-Stimulated Signaling Pathway for Glucose
Transport
Exercise Training Effects on Insulin Sensitivity and Insulin
Signaling
Effects of Calorie Restriction Distinct From Weight Loss
Effects of Calorie Restriction on Insulin Signaling in Skeletal
Muscle
Combined Effects of Exercise and Calorie Restriction
Concluding Remarks
Chapter 10: Mitochondrial Oxidative Capacity and Insulin
Resistance
Kevin R. Short
An Overview of Mitochondrial Structure and Function
Evidence for a Role for Mitochondria in Insulin Resistance and
Diabetes
Evidence That Mitochondria Are Not Responsible for Insulin
Resistance
Concluding Remarks
Chapter 11: Effects of Acute Exercise and Exercise
Training on Insulin Action in Skeletal Muscle
Erik A. Richter and Jï¿œrgen F.P. Wojtaszewski
Exercise and Contraction Signaling in Muscle
Insulin Signaling: A Web
Effect of a Single Bout of Exercise on Insulin Sensitivity
Effects of Exercise Training on Insulin Action
Concluding Remarks
Chapter 12: Resistance Exercise Training and the
Management of Diabetes
Jï¿œrgen F.P Wojtaszewski, Henriette Pilegaard, and Flemming
Dela
Resistance Training and Insulin Sensitivity
Mechanisms Behind Resistance Training–Induced Improvements in
Insulin Sensitivity
Training-Induced Gene Expression
Conclusion and Perspectives
Concluding Remarks
Part IV: Prevention of Type 2 Diabetes: Identification of Novel Molecular Targets and Pathways
Chapter 13: AMPK: The Master Switch for Type 2
Diabetes?
W.W. Winder and D.M Thomson
Discoveries Suggesting AMPK Could Be Important for Prevention and
Treatment of Type 2 Diabetes
Could Type 2 Diabetes Be a Consequence of Deficiency in AMPK
Signaling?
How Can AMPK Activation Help Prevent Type 2 Diabetes?
Can Chemical AMPK Activation Prevent Diabetes?
Feasibility of Using AMPK Activators
Future Directions
Concluding Remarks
Chapter 14: Protein Kinase C and Insulin Resistance
Carsten Schmitz-Peiffer
The PKC Family of Serine or Threonine Kinases
Roles for PKC in Normal Glucose Homeostasis
PKC and Defective Glucose Disposal
Concluding Remarks
Chapter 15: Evidence for the Prescription of Exercise as
a Therapy for the Treatment of Patients With Type 2 Diabetes
Sarah J. Lessard and John A. Hawley
Options for the Treatment of Insulin Resistance and Type 2
Diabetes
Molecular Evidence for the Prescription of Exercise Training
Exercise and Drug Combination Therapy
Exercise-Like Effects of Current Antihyperglycemic Drugs
Prescription of Exercise Training: Practical Considerations
Concluding Remarks
John A. Hawley, PhD, is professor and head of the Exercise Metabolism and Diabetes Research Group in the School of Medical Sciences at the Royal Melbourne Institute of Technology in Melbourne, Australia, where he has a postgraduate research program comprising eight postdoctoral and doctoral students. His areas of research include the regulation of fat and carbohydrate metabolism, with a particular emphasis on insulin resistance and type 2 diabetes, and the role of exercise training in alleviating the metabolic syndrome.
A fellow of the American College of Sports Medicine and a member of the American Physiological Society, Hawley serves as an editorial board member for the American Journal of Physiology: Endocrinology and Metabolism, Sports Medicine, the International Journal of Sport Nutrition and Exercise Metabolism, the International Journal of Sports Physiology and Performance, and the Malaysian Journal of Sport Science and Recreation. Hawley is also a regular reviewer for many international journals.
In 1990, Hawley received the Medical Research Council (MRC) Scholarship for Outstanding Foreign Researcher from the South Africa MRC (1990-1992), which is awarded to assist doctoral studies in medical physiology. Hawley completed his PhD in physiology in 1993 while studying at the University of Cape Town Medical School, South Africa.
Hawley has published more than 150 papers in medical, biochemical, and sport science journals, three books, and 15 book chapters and has served as a visiting lecturer for the University of Otago, New Zealand; the African International Olympic Committee Sports Medicine Program; and the International Olympic Committee Sports Medicine Program. As an invited speaker at conferences and symposiums throughout Europe, the United States, Australia, New Zealand, and Malaysia, Hawley speaks on a range of subjects, including exercise as a therapy for the prevention of metabolic syndrome, mechanisms for improvements in insulin resistance after physical activity, the relationship of exercise to insulin resistance and diabetes, and nutritional strategies and exercise performance.
Juleen R. Zierath, PhD, is professor of physiology and head of the section of integrative physiology in the department of surgical science, Karolinska Institutet, Stockholm, Sweden, and an adjunct professor of biochemistry at Boston University School of Medicine.
Zierath leads an active research group consisting of members representing 10 countries. Through clinical and experimental research approaches, her group has unraveled the signaling mechanisms that mediate hormone action to promote glucose and lipid metabolism. In collaboration with a leading pharmaceutical company, she has contributed to the discovery of a nonprotein insulin receptor agonist that may offer a new type of oral treatment for people with diabetes. Her group collaborates with leading research groups from Scandinavia, Europe, Asia, and North America and is primarily funded by the Swedish Research Council, the Swedish Strategic Research Foundation, and the European Union.
She has published more than 150 peer-reviewed scientific papers, including 35 review articles in journals focused on endocrinology, metabolism, diabetes mellitus, and exercise physiology. She has also coauthored a textbook with Harriet Wallberg-Henriksson on the subject of skeletal muscle metabolism.
Zierath is the recipient of numerous awards, including the Minkowski Award from the European Association for the Study of Diabetes, the Fernstrï¿œm Award from Karolinska Institutet, and a Future Research Leader Award from the Foundation for Strategic Research, Sweden.
“In all, this volume offers a valuable update on factors underlying
the benefits of exercise in the prevention and treatment of type 2
diabetes.”Applied Physiology, Nutrition, and Metabolism
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