Table of Contents

SECTION 1: HEART, ENDOMYOCARDIAL BIOPSY

CONGENITAL/GENETIC

4 Endocardial Fibroelastosis Syndrome

6 Arrhythmogenic Cardiomyopathy

10 Fatty Acid Metabolic Disorders

12 Mitochondrial Myopathies

16 Muscular Dystrophies

20 Glycogen Storage Diseases

22 Fabry Disease, Heart

24 LAMP2 Mutation (Danon Disease)

ACQUIRED

26 Amyloid Deposition, Heart

32 Hemochromatosis, Heart

36 Anthracycline Cardiotoxicity

38 Catecholamine Cardiomyopathy

40 Cocaine Cardiotoxicity

INFLAMMATORY

42 Lymphocytic Myocarditis

46 Giant Cell Myocarditis

48 Eosinophilic (Loeffler) Myocarditis

52 Sarcoidosis, Heart

54 Acute Rheumatic Carditis

58 Eosinophilic Granulomatosis With Polyangiitis

60 Viral Myocarditis

62 Toxoplasmosis, Heart

64 Chagas Disease, Heart

68 Lyme Disease and Rickettsial Myocarditis

72 Lupus Erythematosus, Heart

TRANSPLANT REJECTION

78 Acute Cellular Transplant Rejection, Heart

84 Antibody-Mediated Transplant Rejection, Heart

90 Quilty Lesions

94 Previous Biopsy Sites, Heart Transplant

96 Posttransplant Lymphoproliferative Disorder, Heart

98 Harvesting Injury/Acute Ischemia, Heart

SECTION 2: HEART, RESECTION

HEART EXPLANT

104 Hypertrophic Cardiomyopathy

108 Idiopathic Dilated Cardiomyopathy

112 Ischemic Heart Disease

116 Overview of Coronary Artery Stents

120 Cardiac Allograft Vasculopathy

126 Radiation Injury, Heart

128 Cardiac Conduction System Disease

136 Ventricular Assist Devices

140 Approach to Cardiomyopathy (Worksheet)

142 Approach to Cardiomyopathy Diagnosis

SECTION 3: HEART, TUMORS

BENIGN

150 Cardiac Myxoma

156 Papillary Fibroelastoma

160 Cardiac Rhabdomyoma

164 Cardiac Fibroma

168 Ectopic Tissues, Heart

170 Lipomatous Hypertrophy of the Atrial Septum

MALIGNANT

172 Cardiac Lymphoma

174 Cardiac Angiosarcoma

178 Cardiac Sarcoma, Other

182 Cardiac Metastases

SECTION 4: CARDIAC VALVES, NATIVE

AORTIC

190 Unicommissural Aortic Valve

194 Bicuspid Aortic Valve

198 Senile Calcific Aortic Stenosis

200 Discrete Membranous Subaortic Stenosis

MITRAL

202 Myxomatous Mitral Valve Disease

206 Rheumatic Heart Disease

TRICUSPID

210 Carcinoid Heart Disease

214 Ebstein Anomaly

PULMONARY

216 Congenital Pulmonary Stenosis

ENDOCARDITIS

218 Endocarditis, Native Valve

222 Nonbacterial Thrombotic Endocarditis

SECTION 5: CARDIAC VALVES

PROSTHETIC

228 Leaflet Degeneration, Prosthetic Valves

232 Thrombosis of Prosthetic Valves

234 Endocarditis, Prosthetic Valve

240 Mechanical Heart Valve Prostheses: Modes of Failure

242 Catheter-Deployed Valve Therapies

SECTION 6: PERICARDIUM

INFLAMMATORY

248 Acute Pericarditis

252 Constrictive Pericarditis

254 Tuberculous Pericarditis

TUMORS

256 Lymphoma, Pericardium

258 Metastatic Tumor, Pericardium

262 Mesothelioma, Pericardium

266 Mesothelial/Monocytic Incidental Cardiac Excrescence (MICE)

SECTION 7: VASCULAR DISEASE

ENDARTERECTOMY/ATHERECTOMY/THROM BECTOMY

270 Overview of Peripheral Vascular Specimens

276 Thromboembolus, Vascular

THORACIC AORTA

280 Aortic Degenerative Diseases

288 Genetic Diseases of the Aorta

292 Noninfectious Aortitis

296 Takayasu Arteritis

300 Aortic Dissection

304 Aortic Coarctation

ABDOMINAL AORTA

308 Aortic Atherosclerosis and Complications

314 Chronic Periaortitis and IgG4-Related Disease

316 Mycotic Aneurysm

CORONARY ARTERIES

320 Atherosclerosis, Coronary

324 Coronary Artery Dissection

326 Kawasaki Disease

TEMPORAL ARTERIES

332 Giant Cell/Temporal Arteritis Monica P. Revelo, MD, PhD

PERIPHERAL VESSELS

336 Buerger Disease (Thromboangiitis Obliterans)

340 Fibromuscular Dysplasia

346 Segmental Arterial Mediolysis

348 Mönckeberg Medial Calcific Sclerosis

350 Behçet Disease

354 Infectious Vasculitis

360 Lymphocytic Venulitis

362 Varicosities

364 Hypertensive Renovascular Diseases

VASCULAR TISSUE GRAFTS

368 Vascular Graft Pseudoaneurysm

SECTION 8: VASCULAR TUMORS

BENIGN

374 Hemangioma

384 Angiomyolipoma

388 Glomus Tumor

396 Cystic Lymphangioma

398 Arteriovenous Malformations

MALIGNANT

402 Epithelioid Hemangioendothelioma

406 Kaposi Sarcoma

412 Angiosarcoma

SECTION 9: AUTOPSY

CARDIAC

420 Coronary Artery Bypass Grafting

424 Valve Replacement (Including Transcatheter)

430 Infective Endocarditis

434 Ventricular Assist Device Insertion

438 Heart Transplant

VASCULAR

444 Thoracic Aortic Aneurysm Repair

450 Abdominal Aortic Aneurysm

452 Cerebral Aneurysm and Vascular Malformation

About the Author

Dylan V. Miller is a Professor (Clinical) at the University of Utah School of Medicine's Department of Pathology and is Director of Electron Microscopy and Immunostains at Intermountain Central Laboratory in Salt Lake City, Utah Monica P. Revelo is a Professor at the University of Utah School of Medicine's Department of Pathology, and is Medical Director of Renal and Cardiovascular Pathology at ARUP Laboratories in Salt Lake City, Utah

Reviews

"an important contribution to the literature on cardiovascular pathology and a most welcome source book for practicing pathologists. It encompasses all aspects of cardiovascular diseases with a practical approach."