Table of Contents

Part I: Selected papers of Howard M Temin; Reprint of Temin and Rubin's 1958 paper describing the focus assay for transformation by Rous Sarcoma virus; Reprint of Temin's 1964 paper proposing the DNA provirus hypothesis; Reprint of Boettiger and Temin's 1970 paper on inactivation of BUdR-containing proviral DNA by visible light; Reprint of Temin and Mizutani's 1970 paper reporting the discovery of reverse transcriptase; Reprint of Temin's 1971 paper proposing the protovirus hypothesis; Part II: Cancer; On the origin of oncogenes; Viruses, genes and cancer: a lineage of discovery; Mammaliam development and human cancer: from the phage group to the genetics of intestinal cancer; Malignant transformation of cells by the v-Rel oncoprotein; Progress in the molecular medicine of cancer; Part III: Virology; Reprint of Shimotohno, Mizutani and Temin's 1980 paper on the similarity of the structure of retroviral proviruses to that of transposable elements; Beyond the provirus: from Howard Temin's insights on Rous Sarcoma virus to the study of Eppstein-Barr virus, the prototypic human tumor virus; Under the influence: from the provirus hypothesis to multistep carcinogenesis; Herpes simplex virus DNA replication and genome maturation; Reprint of Temin's 1993 paper on the inherent contributions of reverse transcription to retroviral variation; Retrovirus variation and evolution; Part IV: HIV, AIDS and the immune system; Human retroviruses in the second decade: some pathogenic mechanisms and approaches to their control; Cherish an idea that does not attach itself to anything; Gene therapy in CD4+ T lymphocytes in SCID-hu mice; The dilemma of developing and testing AIDS vaccines; reprint of temin's 1993 paper proposing a new approach to develop a human immunodeficiency virus vaccine