Table of Contents

1. Preanalytical Variation 2. Statistical Methods in Laboratory Medicine 3. Reference Intervals: Theory and Practice 4. Method Validation: Finding (and Fixing) the Error of Our Testing Ways 5. Quality Control 6. Laboratory Calculations 7. Spectrophotometry 8. Chromatography and Electrophoresis 9. Electrochemistry 10. Mass Spectrometry 11. Nuclear Magnetic Resonance Technology and Clinical Applications 12. Immunoassays 13. Nucleic Acid Probes Used in the Analysis of DNA 14. The Polymerase Chain Reaction 15. Laboratory Automation 16. Regulatory Issues 17. Principles of Laboratory Management 18. Evidence-Based Laboratory Medicine 19. Harmonization of Results Among Laboratories 20. Laboratory Information Systems 21. Point-of-Care Testing 22. Proteins: Analysis and Interpretation in Serum, Urine, and Cerebrospinal Fluid 23. Hemoglobin Variant Detection 24. Hemostasis: The View from the Clinical Chemistry Laboratory 25. Laboratory Diagnosis of Lipid and Lipoprotein Disorders 26. Biomarkers for Acute Cardiovascular Diseases and Heart Failure 27. Laboratory Diagnosis of Liver Disease 28. Clinical Chemistry of the Gastrointestinal Disorders 29. Evaluation of Exocrine Pancreatic Function 30. Carbohydrate Disorders 31. Laboratory Evaluation of Kidney Function 32. Blood Gas and Critical Care Testing 33. Water and Electrolyte Balance 34. Urinalysis 35. Disorders of the Anterior and Posterior Pituitary 36. Laboratory Evaluation of Thyroid Function 37. Disorders of the Adrenal Cortex and Medulla 38. Laboratory Testing in Pregnancy and Reproductive Disorders 39. Tumor Markers 40. Calcium Biology and Disorders 41. Vitamins and Trace Elements: Functions and Assessment of Status through Laboratory Testing 42. Inborn Errors of Metabolism 43. The Porphyrias: Fundamentals and Laboratory Assessment 44. Pharmacokinetics for the Practicing Clinical Chemist 45. Therapeutic Drug Monitoring 46. Toxicology and the Clinical Laboratory 47. Pharmacogenetics 48. Applications of Molecular Techniques in the Clinical Laboratory 49. Infectious Disease 50. Pediatric Laboratory Medicine 51. Diagnostic Body Fluid Testing

About the Author

Dr. William Clarke is a Professor of Pathology at the Johns Hopkins University School of Medicine. His research focuses on the development of analytical methods for drug analysis, clinical mass spectrometry, and devices for point-of-care testing. He serves as the director of Clinical Toxicology for Johns Hopkins Hospital, as well as the Point-of-Care Testing Program for Johns Hopkins Medicine. Dr. Mark Marzinke is Associate Professor of Pathology and Medicine at the Johns Hopkins University School of Medicine.Dr. Marzinke serves as the Director of General Chemistry in the Johns Hopkins Hospital Core Laboratories, and is the Director of the Clinical Pharmacology Analytical Laboratory within the Division of Clinical Pharmacology. He is also Co-Director of the HIV Prevention Trials Network Laboratory Center.