PART ONE: Performing Clinical Research

Forming Research Questions.... 3

Conducting Systematic Reviews.... 15

Finding Information About the Burden of Disease.... 49

An Introduction to Performing Therapeutic Trials.... 59

The Tactics of Performing Therapeutic Trials.... 66

The Principles Behind the Tactics of Performing Therapeutic Trials.... 173

Testing Quality Improvement Interventions.... 244

Evaluating Diagnostic Tests.... 273

Determining Prognosis and Creating Clinical Decision Rules.... 323

Assessing Claims of Causation.... 356

Generating Outcome Measurements, Especially for Quality of Life.... 388

PART TWO: Becoming a Clinical Researcher

Becoming a Successful Clinician-Investigator.... 415

Preparing a Research Protocol to Improve its Chances for Success.... 429

Online Data Collection.... 440

Analyzing Data.... 446

Preparing Reports for Publication and Responding to Reviewers' Comments.... 461

Dealing with the Media.... 474
Index.... 487