Historical Perspectives.- Adrenergic Receptors.- Structure-Function.- Ligand Binding, Activation, and Agonist Trafficking.- New Signal Transduction Paradigms.- Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors.- Adrenergic Receptors in Clinical Medicine.- Imaging Adrenergic Receptors and Their Function.- Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors.- Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors.- Genetically Altered Mouse Models.- The ?1-Adrenergic Receptors.- The ?2-Adrenergic Receptors.- The ?-Adrenergic Receptors.- Lessons From Overexpressed Mouse Models.- Adrenergic Receptor Signaling Components in Gene Therapy.- Pharmacogenomics.- Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms.- Microarray Analysis of Novel Adrenergic Receptor Functions.- Summary and Future Endeavors.- Summary and Future Endeavors.
From the reviews: "...useful to anyone interested in adrenoceptor physiology/pharmacology or in the design of drugs interacting with the receptor or its signal transduction pathway." -Journal of Medicinal Chemistry "Dianne Perez has assembled a number of important contributors to the research area and grouped the 15 chapters into six parts. … many MDs, biologists, and pharmacologists will find the book … appealing, as the receptor class is involved in numerous cardiovascular and pulmonary diseases." (Boris Schmidt, ChemMedChem, Issue 1, 2006)
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