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Reviews how medicinal chemists are employing the bioactive properties of validamycin and its related agricultural antibiotics in novel pharmaceutical drugs

Table of Contents

1. An Introduction to Validamycins and Their Derivatives 2. Production of Validamycins 3. Bioactivities of Validamycins and Related Natural Compounds 4. Chemical Synthesis of Validamycin and Related Natural Compounds 5. Voglibose: An Important Drug for Type 2 Diabetes 6. N-Octyl-ß-Valienamine and N-Octyl-4-epi-ß-Valienamine: Two Highly Potent Drug Candidates for Chemical Chaperone Therapy 7. Prospects and Concluding Remarks

About the Author

Professor Chen and his team have decades of experience working with Validamycin. Their research originally spanned its initial discovery, development and production as an agricultural antibiotic, and is now focussed on exploring its recent adaptation to a pharmaceutical lead with a multitude of potential applications. The group have published numerous papers on their work, including an important review on the preparation of Validamycin derivative Valienamine in 2003, followed by another key review on the preparation of Voglibose in 2006. In addition, they hold a number of patents relating to the degradation of Validamycin to produce Valienamine. Institute of Fermentation Engineering, Zhejiang University of Technology, PR China Institute of Fermentation Engineering, Zhejiang University of Technology, PR China Institute of Fermentation Engineering, Zhejiang University of Technology, PR China