Table of Contents

Contributing Authors Preface Part I Background * Applied Pain Neurophysiology Serge Marchand* Toward a Rational Taxonomy of Analgesic Drugs David Lussier and Pierre BeaulieuPart II Specific Pharmacological Pain Targets * Targeting the Cyclooxygenase Pathway Pascale Vergne-Salle and Jean-Louis Beneytout* Pharmacology and Mechanism of Action of Acetaminophen Christophe Mallet and Alain Eschalier* Pharmacology of the Opioid System Christopher J. Evans, A. Charles, J.C. Marvizon, and Y. Ma* Pharmacology of the Cannabinoid System Josee Guindon, Pierre Beaulieu, and Andrea G. Hohmann* Sodium Channels in Pain Pharmacology Theodore R. Cummins and Stephen G. Waxman* Potassium and Calcium Channels in Pain Pharmacology Sergio H. Ferreira, Wiliam A. Prado, and Luiz F. Ferrari* Toward Deciphering the Respective Roles of Multiple 5-HT Receptors in the Complex Serotonin-Mediated Control of Pain Valerie Kayser, Sylvie Bourgoin, Florent Viguier, Benoit Michot, and Michel Hamon* Glutamate and GABA Receptors in Pain Transmission Ke Ren and Ronald Dubner* Dopamine Pathways and Receptors in Nociception and Pain Francisco Pellicer, J. Manuel Ortega-Legaspi, Alberto Lopez-Avila, Ulises Coffeen, and Orlando Jaimes* Neurotrophic Factors, Neuropeptides, and Nitric Oxide: Therapeutic Targets in Chronic Pain Mechanisms Amelia A. Staniland, Jean-Sebastien Walczak, and Stephen B. McMahon* Cytokines, Chemokines, and Pain Claudia Sommer and Fletcher White* Adenosine Triphosphate and Adenosine Receptors and Pain Geoffrey Burnstock and Jana Sawynok* The Transient Receptor Potential (TRP) Family in Pain and Temperature Sensation Gehoon Chung, Sung Jun Jung, and Seog Bae Oh* Adrenergic and Cholinergic Targets in Pain Pharmacology Ralf Baron and Wilfrid Janig* New Pain Treatments in Late Development Andre Dray and Martin N. PerkinsPart III Special Topics in the Pharmacology of Pain * Vulnerability to Opioid Tolerance, Dependence, and Addiction: An Individual-Centered Versus Drug-Centered Paradigm Analysis Guy Simonnet and Michel Le Moal* Pharmacogenetics of Pain Inhibition Jeffrey S. Mogil* Placebo Analgesia Philippe Goffaux, Guillaume Leonard, Serge Marchand, and Pierre Rainville* Current Animal Tests and Models of Pain Daniel Le Bars, Per T. Hansson, and Leon PlaghkiPart IV Clinical Pharmacology of Pain * Pharmacological Considerations for the Obstetric Patient John S. McDonald and Wing-Fai Kwan* Pharmacological Considerations in Infants and Children Stephen C. Brown, Anna Taddio, and Patricia A. McGrath* Pharmacological Considerations in Older Patients David Lussier and Gisele Pickering* Pharmacological Considerations in Obese Patients and Patients with Renal or Hepatic Failure Frederique Servin* Pharmacological Considerations in Palliative Care Maxine Grace J. de la Cruz and Eduardo BrueraIndex

About the Author

Pierre Beaulieu, MD, PhD, FRCA, is Associate Professor of Pharmacology and Anesthesiology at the University of Montreal, Quebec, Canada. He received his MD at the University of Bordeaux, trained in anesthesiology in London, UK, and received his PhD in pharmacology in Montreal. His research concentrates on the pharmacology of cannabinoids in the treatment of pain through the modulation of the endocannabinoid system. David Lussier, MD, obtained his medical degree from the University of Montreal and completed training in pain medicine and palliative care at Beth Israel Medical Center. He is now Associate Professor at University of Montreal, Adjunct Professor at McGill University, a member of McGill's Alan-Edwards Center for Research on Pain, and a physician at the University of Montreal Geriatric Institute and the McGill University Health Center. Frank Porreca, PhD, is Professor of Pharmacology and Anesthesiology at the University of Arizona. He received his MS in biomedical engineering at Drexel University and his PhD in pharmacology at Temple University. His current research includes mechanisms of neuropathic and other chronic pains, headache pain, opioid-induced hyperalgesia, and new modalities for treatment of pain and drug abuse. Anthony Dickenson, PhD, FMedSci, is Professor of Neuropharmacology in the Department of Pharmacology at University College, London, UK. He gained his PhD at the National Institute for Medical Research, London, and was appointed to the Department of Pharmacology at University College in 1983. He is a founding and continuing member of the Wellcome Trust-funded London Pain Consortium.