Table of Contents

Part 1 Retrospective look at earlier advances: molecular nature, conjugal transfer and replication of extrachromosomal elements 1961 to 1973; R plasmids and antibiotic resistance; transposon Tn3, 1973 to 1980; enterotoxic escherichia coli, 1971 to 1979; molecular epidemiology - development and application of molecular methods to solve infectious disease mysteries. Part 2 Adhesins: adherence mechanisms in urinary tract infections; escherichia coli type 1 pili; mechanisms of pilus antigenic variation in neisseria gonorrhoea; type 4 pili in the families moraxellaceae and neisseriaceae; genes for the filamentous haemagglutinin and fimbriae of bordetella pertussis - co-location, co-regulation and co-operation?; early events in the pathogenesis of haemophilus influenzae disease; molecular pathogenesis of enteropathogenic escherichia coli; murine colonic hyperplasia. Part 3 Molecular and cellular biology of intracellular bacteria: genetic approaches to understanding salmonella pathogenicity; mechanisms of yersinia entry into mammalian cells; cell biology of salmonella pathogenesis; intracellular trafficking of legionella pneumophila within phagocytic cells; cellular biology of listeria monocytogenes infection; determinants of chlamydial pathogenesis and immunity. Part 4 Extracellular structures and products: genetic analysis of the escherichia coli K1 capsule gene cluster; type III capsular polysaccharide of group B streptococci - role in virulence and the molecular basis of capsule expression; unorthodox secretion by gram-negative bacteria; holistic perspective on the escherichia coli haemolysin; YOPS of the pathogenic listeria SPP; role of flagella in campylobacter pathogenesis; molecular biology and role in disease of the vero- (shiga-like) toxins of escherichia coli. Part 5: Virulence gene regulation: co-ordinate regulation of virulence in bordetella pertussis mediated by the vir/bvg locus; methylation-dependent and lrp-dependent fimbrial gene regulation in escherichia coli; the tao of urease; pJM1 plasmid-mediated iron transport-virulence system of vibrio anguillarum. Part 6 Other aspects of bacterial pathogenesis: role of sucrose metabolism in the carcinogenicity of the mutans streptococci; how many bacteria does it take to cause diarrhoea and why?; genetics as a route toward mucosal vaccine development; phylogenetic diversity of microbial pathogens.