INTRODUCTION SECTION 1 - DIAGNOSIS AND CLASSIFICATION 1.1 Introduction. i. Brief description of nature of disease. ii. Brief description of types of diabetes. iii. Demographics - Prevalence figures U.K & worldwide. Obesity epidemic. iv. Outline of book. 1.2. Pre-Diabetes i. Case scenario 1 - Diabetes diagnosis. ii. Who is at risk for type 2 diabetes? iii. Diabetes prevention. 1.3. Type 2 Diabetes - Presentation i. Case scenario 1 - opportunistic diagnosis ii. Case scenario 2 - presentation with symptoms 1.4. Type 1 Diabetes - Presentation i. Case scenario 9 - presentation in childhood ii. Case scenario 10 - presentation in adulthood with DKA 1.5. Rarer forms of Diabetes - Presentation i. Case scenario 3 - iatrogenic (drug induced) ii. Case scenario 4 - MODY iii. Case scenario 5 - Endocrine causes ( Cushing's) iv. Case scenario 6 - Pancreatic causes (chronic pancreatitis) v. Case scenario 7 - Gestational diabetes. vi. Case scenario 8 - LADA SECTION 2 - MANAGEMENT 2.1. Lifestyle Modification and the Management of Obesity i. Diet (2) ii. Exercise (2) iii. Orlistat. iv. Bariatric surgery v. Smoking and alcohol 2.2. Oral Hypoglycaemic Drugs i. Metformin (2) ii. Sulphonylureas (1) iii. Pioglitazone (2) iv. Incretin mimetics (1) v. Less commonly prescribed drugs - acarabose, naglitinides. vi. Monitoring of glycaemic control 2.3. Insulin i. Indications for insulin (1) ii. Pros and cons of insulin. iii. Different type of insulin. iv. Storage and administration of insulin. v. Insulin pumps vi. Self-monitoring of blood glucose. 2.4. Diabetes in Special Circumstances i. Pregnancy (7) ii. Childhood (9) iii. Case scenario 11 - adolescence iv. Elderly (1) v. Hospital in-patients (2) SECTION 3 - COMPLICATIONS 3.1. Acute Metabolic Complications i. Hypoglycaemia ii. Hyperosmolar state iii. Diabetic ketoacidosis 3.2. Microvascular Complications i. General ii. Retinopathy & other causes of diabetic eye disease. (9) iii. Nephropathy (9) iv. Neuropathy (10) v. Sexual dysfunction (10) vi. Diabetic foot disease (1) 3.3. Macrovascular Complications i. The risk of cardiovascular disease. ii. Cholesterol reduction iii. Blood pressure management iv. Aspirin v. Treatment after a heart attack CONCLUSION Future Developments i. Artificial pancreas ii. New drugs iii. Pancreatic, islet cell and stem cell transplants
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