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Human Embryology and Developmental Biology
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Table of Contents

Developmental Tables

Carnegie Stages of Early Human Embryonic Development (Weeks 1-8)

Major Developmental Events During the Fetal Period

PART I Early Development and the Fetal-Maternal Relationship

CHAPTER 1
Getting Ready for Pregnancy
Gametogenesis
Preparation of the Female Reproductive Tract For Pregnancy
Hormonal Interaction Involved with Reproduction in Males

CHAPTER 2
Transport of Gametes and Fertilization
Ovulation and Egg and Sperm Transport
Fertilization

CHAPTER 3
Cleavage and Implantation
Cleavage
Embryo Transport and Implantation

CHAPTER 4
Molecular Basis for Embryonic Development
Transcription Factors
Signaling Molecules
Receptor Molecules
Signal Transduction
Retinoic Acid
Developmental Genes and Cancer

CHAPTER 5
Formation of Germ Layers and Early Derivatives
Two-Germ-Layer Stage
Gastrulation and the Three Embryonic Germ Layers
Induction of the Nervous System
Cell Adhesion Molecules

CHAPTER 6
Establishment of the Basic Embryonic Body Plan
Development of the Ectodermal Germ Layer
Development of the Mesodermal Germ Layer
Development of the Endodermal Germ Layer
Basic Structure of 4-Week Old Embryo

CHAPTER 7
Placenta and Extraembryonic Membranes
Extraembryonic Tissues
Chorion and Placenta
Placental Physiology
Placenta and Membranes in Multiple Pregnancies

CHAPTER 8
Developmental Disorders: Causes, Mechanisms, and Patterns
General Principles
Causes of Malformations
Developmental Disturbances Resulting in Malformations

PART II Development of the Body Systems

CHAPTER 9
Integumentary, Skeletal and Muscular Systems
Integumentary System
Skeleton
Muscular System

CHAPTER 10
Limb Development
Initiation of Limb Development
Regulative Properties and Axial Determination
Outgrowth of Limb Bud
Morphogenetic Control of Early Limb Development
Development of Limb Tissues

CHAPTER 11
Nervous System
Establishment of Nervous System
Early Shaping of Nervous System
Histogenesis Within the Central Nervous System
Craniocaudal Pattern Formation and Segmentation
Peripheral Nervous System
Autonomic Nervous System
Later Structural Changes in the Central Nervous System
Ventricles, Meninges, and Cerebrospinal Fluid Formation
Cranial Nerves
Development of Neural Function

CHAPTER 12
Neural Crest
Origins of Neural Crest
Migrations of Neural Crest
Differentiation of Neural Crest Cells
Major Divisions of Neural Crest

CHAPTER 13
Sense Organs
Eye
Ear

CHAPTER 14
Head and Neck
Early Development of Head and Neck
Establishing the Pattern of the Craniofacial Region
Development of Facial Region
Formation of the Teeth
Development of Pharynx and Its Derivatives

CHAPTER 15
Digestive and Respiratory Systems and Body Cavities
Digestive System
Respiratory System
Body Cavities

CHAPTER 16
Urogenital System
Urinary System
Genital System
Sexual Duct System
External Genitalia

CHAPTER 17
Cardiovascular System
Developmental of Blood and the Vascular System
Developmental and Partitioning of Heart
Fetal Circulation

CHAPTER 18
Fetal Period and Birth
Growth and Form of Fetus
Fetal Physiology
Parturition
Adaptations to Postnatal Life
Overview

Answers to Clinical Vignettes and Review Questions

Index

About the Author

Bruce M. Carlson, MD, PhD, is Professor Emeritus of Anatomy in the Department of Cell and Developmental Biology in the University of Michigan Medical School in Ann Arbor. He served as chair of that department from 1998-2000. He is also Research Professor Emeritus in the school's Institute of Gerontology, of which he was the director from 2000 to 2003. Professor Carlson writes the majority of the book himself but he has suggested that he may bring in one or two contributors this time round to cover areas that he is not as up to date on as he once was. We have spoken about bringing in a co-author and he is open for this to happen for the 7th edition when he has had time to find someone suitable.

Reviews

"This book covers in depth the structures and mechanisms of early human embryonic development from the prefertilization period through organogenesis and provides access to the Student Consult website, which includes downloadable full-color illustrations and animated videos showing select developmental processes. The book includes numerous boxed clinical correlations, case vignettes, and review questions with answers. The illustrations are excellent and include several new scanning electron micrographs and clinical case photographs. The revision of chapter 12, on the neural crest, is especially valuable as it effectively consolidates the latest information regarding the complex role of this tissue in development. Grouping the integumentary, skeletal, and muscular systems together in chapter 9 may confuse readers, as these tissues primarily arise from different primordia. The extensive passages on molecular processes and signaling pathways may be daunting to readers lacking a foundation in molecular biology or genetics, and the book would benefit from placing these sections under separate subheadings. In addition, it would be helpful to include chapter information in the page headers, as well as a glossary."-Erin Leslie, PhD(Midwestern University) Doody Review: 4 stars

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