Table of Contents

Acknowledgements ix Terminology xiii Guest forewords: 'voices for the park' xv Author's preface xix Introduction 1 Brief timeline 3 PART I: HISTORIC ALDERLEY PARK 1 The early park & land 8 When was Alderley Park named? 8 Stanleys, Eagle and Child 11 Senior and junior Stanleys; Shakespeare 16 The Park's situation and weather 19 Rocks and views of the Park 21 2 Baronets to baron 23 The Old Hall and its Baronets to 1779 23 Beeches and avenues of the Park 29 The Alderley House mansion 32 John Thomas, 1st Lord Stanley of Alderley 36 Alderley Edge and its railway; the Cottontots 41 Heraldry of the Tenants' Hall 42 3 Elegance and water 44 The Water Garden and grounds 44 The Adam gates 48 Alderley House Arboretum 50 Reverend Edward Stanley & his birds 51 The History of Radnor Mere 53 Further Lords Stanley of Alderley 58 Lords after the Park 66 The smaller waters of Alderley Park 67 4 Remembering 72 Tenants' Hall to Conference Centre 72 The Alderley Mummers 75 The art and photography of the Park 77 Alderley Park WHOLE BOOK.indd 5 19/02/2016 10:22:37 vi CONTENTS The Great 1938 Sale 80 Surviving old buildings of the Park 83 Old maps of the Park 88 Nether Alderley: Old Hall and Church 90 Wartime activities and noise! 92 PART II: NATURAL ALDERLEY PARK 5 Nature recording in the park 98 Discovering the living Park 98 Wildlife recording in Alderley Park 98 Biodiversity in Alderley Park 103 6 Species of the park 106 Birds of Alderley Park 106 Mammals of the Park 114 Bats of the Park 117 Butterflies and other insects 119 Dragonflies of the Park 120 Plant records and orchids in the Park 122 Fish in the Park 124 PART III: GREEN ALDERLEY PARK 7 Farm and estate 128 Historical farming and use of the land 128 Woodland: mature and managed 129 Matthews and flowers 132 Estate farms old and new: sheep! 134 Making the Park greener 136 8 Alderley Park Farm open days 138 People in the Park 138 The Park's History and Nature Trails 139 Icicals to ClubAZ 141 Mulberry's and Sport 145 Estate in the local community 147 Image, Communications and charity 148 PART IV: GLOBAL ALDERLEY PARK 9 Company beginnings 152 'Pharms' - the early history 152 ICI's choice; building begins 1955-64 163 IHRL and CTL 169 Foundational products 172 Animal medicine 174 Alderley Park WHOLE BOOK.indd 6 19/02/2016 10:22:37 CONTENTS vi i 10 Historic milestones 178 Heart Drugs 1: 'Inderal' (propranolol) 178 Heart Drugs 2: 'Tenormin' (atenolol) 183 'Nolvadex' (tamoxifen) - discovery 186 'Nolvadex' (tamoxifen) - launch 195 The antibacterial search 200 Anaesthetics - 'Fluothane' to 'Diprivan' 203 11 Supporting the work 208 Engineering and labs 208 Facilities and services 210 Office life 215 Computers - starting from one 216 Finance, budget, investment 221 Procurement and consumables 222 12 Route to the patient 224 Scientists and sciences 224 Analysis, spectra and drug properties 230 Samples, the Collection and Weighing 234 Patents and Intellectual Property 235 Drug Development and Safety 237 Clinical Trials and Regulatory Affairs 239 Process, Manufacture, 'Macc. Works' & Purity 243 Launching - World Market - Patient Safety 244 13 Growing and telling 248 Building in the Park: 1965-90 248 Staff and message - publications 254 Publishing the science 257 Dealing with humans ... 258 Dealing with e-mail 262 Collaborating with academia 263 Education, training and the young! 264 Collaborating with colleagues 265 14 The big new world 267 Information Systems 267 Information Technology 268 Keeping tabs on the competition 270 Sites overseas: links to the globe 271 Hanson, demerger & Zeneca 272 Merger - to AstraZeneca 276 Rational drug design & molecular modelling 278 Robots and technology 281 Alderley Park WHOLE BOOK.indd 7 19/02/2016 10:22:37 viii CONTENTS 15 Targets & hormones 283 Choosing targets 283 Prostate cancer 1: 'Zoladex' 285 Prostate cancer 2: 'Casodex' 288 Breast cancer again 1: 'Faslodex' 290 Breast cancer again 2: 'Arimidex' 293 16 Wider horizons still 296 Widening the target: 'Tomudex' 296 The Big C: 'Iressa' 297 Multiple pathways: 'Caprelsa' 301 A perfect project: 'Tagrisso' 303 A site in constant growth: 1993-2008 310 17 Value judgement 315 Approaching the cliff 315 Ethics, testing and public support 316 Safe at work 318 Alderley Park's 15 drugs (so far!) 319 Five more worked on in the Park 321 Therapeutic areas: painful failures 326 18 People, time & chance 328 Changing of the guard - CEOs 328 Not as planned ... 329 Another great sale 330 PART V: LIVING ALDERLEY PARK 19 And now, the future 336 Manchester Science Partnerships 336 Faith and future in the Park 340 The question of research 343 Afterword 346 Appendix 1: Historical tables 347 Appendix 2: Wildlife checklists 349 Appendix 3: What and who 353 Appendix 4: Companies leadership 355 Appendix 5: The Park's famous scientific papers & patents 356 References 359 Bibliography 366 Index 369 List of subscribers 377

About the Author

George B. Hill was born in 1956. He joined ICI after a first class honours degree in chemistry at UMIST (Manchester), and worked as a synthetic organic research chemist in 'the Park' for 34 years, half of it on projects in oral health, arthritis and antibiotics and the other half in the cancer area; he was a team member on the Faslodex(TM) and Tagrisso(TM) projects. His name is on 12 scientific papers, three as lead author. Outside science, he wrote the texts for the five Alderley Park History & Nature Trail guides; and edited the annual Alderley Park & Radnor Mere Wildlife Report from 1978 to 2011. He left AstraZeneca in 2012. George lives with his wife Christine in Cheshire where they are active at their local Baptist church. They have three wonderful grown-up children (one is a chemist). George now writes in several genres combining fiction, science, faith, history and poetry. His 'My Writing' website at www.hillintheway.co.uk has details of his (mostly self-published) work.